See full prescribing information for complete boxed warning. N42methyl24methylsulfonylaminophenoxyethylaminoethylphenylmethanesulfonamide dofetilide is a white to offwhite powder. Open your powerpoint presentation on the page you want to insert the pdf within. Do not minimize your pdf window, and make sure its the last window you have open before moving to the next step. Other effects may not be serious but may cause concern. Mavenclad 10mg tablets summary of product characteristics. Highlights of prescribing information hypersensitivity to. Mar 17, 2020 cladribine is used to treat relapsing multiple sclerosis ms in adults.
Safety of cladribine tablets in the treatment of patients with multiple. Each subcutaneous dose should be injected as a single injection into abdominal tissue at approximately 24 hour intervals. Medlineplus information on cladribine a lay language summary of important information about this drug that may include the following. Each treatment course consists of two treatment weeks, one at the beginning of the first month and one at the beginning of the second month. Cladribine is used to treat a certain type of cancer hairy cell leukemia. Cladribine side effects, dosage, interactions drugs. Jan 01, 2017 cladribine belongs to the group of medicines called antimetabolites. Other this section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. This will embed the pdf file into the slide you have selected. Since the growth of normal body cells may also be affected by cladribine, other effects will also occur. This emedtv segment explains how this chemotherapy treatment works, describes how the drug is given, lists potential side effects, and more. There was no increase in malignancy rates for cladribine in patients with. Systemic mastocytosis sm is a disorder, defined by mast cell hyperplasia, for which no curative therapy is currently available. Cladribine injection leustatin side effects, medical.
Using concomitant drugs of the 5ht 3 antagonist class including antiemetics e. Identification of patients with ms who may benefit from treatment with dmts with properties. This guidance has been updated and replaced by nice technology appraisal guidance 616. Leustatin cladribine injection for intravenous infusion only. Cladribine is a purine analogue which passively enters cells and is phosphorylated by deoxycytidine kinase. Since the growth of normal body cells may also be affected by cladribine. As is the case for fludarabine, where intravenous versus oral drug costs per milligram are similar, that is, 2. Cladribine is regarded a firstline treatment of advanced forms of sm.
The benefitrisk balance of cladribine in patients with rrms and specifically patients with. You have fewer relapses than you might have had with no treatment. I rolled up my top and had two 5ml injections of cladribine into my stomach. A pdf document is filled with all kinds of content, including text or images, that you might want to import elsewhere. Cladribine may also be used for purposes not listed in this medication guide. In the insert pages dialog box, specify where to insert the document before or after the first or last page. Jul, 2010 cladribine is a small molecule that may interfere with the behavior and the proliferation of certain white blood cells, particularly lymphocytes, which are thought to be involved in the pathological process of ms. Some of these may be serious and must be reported to your doctor.
Cladribine, sold under the brand name leustatin among others, is a medication used to treat hairy cell leukemia hcl, leukemic reticuloendotheliosis, bcell chronic lymphocytic leukemia and relapsingremitting multiple sclerosis rrms. Technology appraisal guidance ta493 published date. Cladribine is usually given after other treatments have failed. Merck kgaas cladribine tablets for ms approved in russia. One group of patients received cladribine in year 1 and placebo in year 2 and had a mean relapserate of 0. May 18, 2018 cladribine injection should be passed through a sterile 0.
Convert pdf to powerpoint convert your pdfs to powerpoint. How to insert a pdf into powerpoint online tech tips. Embryofetal toxicity, hematologic toxicity, and venous and arterial. Cladribine is used to treat hairy cell leukemia a type of blood cancer. If your pdf is in a presentation format, the conversion should be no problem. Safety and efficacy of cladribine tablets in patients with relapsing. Revlimid lenalidomide capsules, for oral use initial u. Before we begin, you should be aware of the two ways you can do this.
In august 2017, cladribine was approved for the treatment of people with highly active relapsing forms of ms in the european union, norway, liechtenstein, and iceland. Multiple sclerosis ms is an inflammatory neurodegenerative disease of the central nervous system. Combine or merge files into a single pdf, adobe acrobat dc. Cladribine is a chemotherapeutic agent that targets white blood cells and is used to treat certain blood cancers. Dec 14, 2009 contains inactivated ndc codes ndc codes. Dadenosine is a synthetic antineoplastic agent for continuous intravenous infusion. Click on the create from file button and then click browse. Cladribine gets european approval in ms medpage today. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into dna, resulting in singlestrand breaks in dna, depletion of nicotinamide adenine dinucleotide and adenosine triphosphate, and apoptosis. Cladribine stops these cells, especially the b cells, from getting into your brain and spinal cord, so they cant damage the nerves there. Leustatin cladribine injection also commonly known as 2chloro2deoxy. Progressive multifocal leukoencephalopathy in a patient. Administration of first treatment course first coursefirst cycle.
To bring you great quality, smallpdf has partnered with solid documents that offers the best conversion out there. Turn your pdf presentations to editable powerpoint ppt and pptx slideshows. This causes breaks in dna strands and leads to cell death. Work with the most accurate pdf to powerpoint converter. Dck is the rate limiting enzyme for conversion of the cladribine prodrug into its active triphosphate form, leading to selective depletion of dividing and nondividing t and b cells. However, the product of the reaction is resistant to deamination and accumulates as there is little deoxynucleotidase activity in lymphocytes. Anderson cancer center study b, 35 patients were treated with a 7day continuous intravenous infusion of cladribine injection at a comparable dose of 3.
Cladribine cladribine dose, indications, adverse effects. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents. Cladribine tablets for treating relapsingremitting. Leustatin cladribine injection for intravenous infusion. Both men and women should use effective birth control to prevent pregnancy while taking cladribine, and for 6 months after the last dose if you use birth control pills or other hormonal forms implants, skin patches, vaginal rings, also use a barrier form of birth control condom, diaphragm, cervical cap, contraceptive. If youre creating a microsoft powerpoint presentation, you can insert a pdf document by following these steps.
Cladribine plasma concentration after intravenous administration declines multiexponentially with an average halflife of 6. Cladribine is also being studied in the treatment of other types of cancer. Jan 21, 2020 dck is the rate limiting enzyme for conversion of the cladribine prodrug into its active triphosphate form, leading to selective depletion of dividing and nondividing t and b cells. Cladribine fdas top blockbuster decisions fiercebiotech. Mavenclad is a disease modifying drug dmd for very active relapsing remitting ms. I was already in the outpatient room, on the bed, having just had a lumbar puncture more about that below. Insert pdf file content into a powerpoint presentation.
It is used to treat hairy cell leukemia, a cancer of the blood and bone marrow. Each treatment course consists of two treatment weeks, one at the beginning of the first month and one at. If neither of those two methods work for your needs, you can also add a pdf file into a. Sections or subsections omitted from the full prescribing information are not. Because of the potential for serious adverse effects in breastfeeding infants from cladribine, discontinue breastfeeding or discontinue intravenous cladribine, taking into account the.
My cladribine experience multiple sclerosis society. Benefitrisk assessment of cladribine using multicriteria decision. Cladribine interferes with the growth of cancer cells, which are eventually destroyed. Highlights of prescribing information these highlights do not. Cladribine is a cancer medication that interferes with the growth and spread of cancer cells in the body. It is also sometimes used to treat other kinds of cancer, as determined by your doctor. Highlights of prescribing information these highlights do not include all the information needed to use revlimid safely and effectively. The reconstituted solution contains 5,000 international units iuml. Open the pdf that you want to insert a picture of, and then switch to powerpoint. To do this, click on the insert tab and then click on object. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Cladribine by injection national library of medicine. Prospective observational longterm safety registry of.
Cladribine 2mgml solution litak from lipomed, available via aah is the only licensed product for subcutaneous use. Lemtrada alemtuzumab injection, for intravenous use. Leustatin injection must be diluted in designated intravenous solutions prior to administration see dosage and administration. Effect of cladribine tablets on lymphocyte reduction and repopulation. This guidance has been updated and replaced by cladribine for treating relapsingremitting multiple sclerosis.
Up to 7ml may be injected into one site and there is no. Cladribine tablets for treating relapsingremitting multiple. Cladribine is a small molecule that may interfere with the behavior and the proliferation of certain white blood cells, particularly lymphocytes, which are thought to be involved in the pathological process of ms. Cladribine tablets for treating relapsingremitting multiple sclerosis. Cladribine is a purine nucleoside antimetabolite analogue. Because of the small number of events, an excess mortality due to tikosyn cannot be ruled out with confidence in the pooled survival analysis of placebocontrolled trials in. In the eu summary of product characteristics smpc, criteria for. Cladribine can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, or pain or arthritis including aspirin, tylenol, advil, and aleve. In a longterm followup study of cladribine in mastocytosis, efficacy was found significant and safety acceptable.
It has not been approved for use in the united states or canada. In an analysis of 506 diamond patients with atrial fibrillationflutter at baseline, one year mortality on tikosyn was 31% vs. It is a clear, colorless, sterile, preservativefree, isotonic solution. Dosage is based on your weight and response to treatment. Progressive multifocal leukoencephalopathy in a patient with. Cladribine injection leustatin side effects, medical uses.
Withdraw volume of reconstituted elspar containing calculated dose into sterile syringe. The pen injector is provided in a package with six needles. Definition from the nci drug dictionary detailed scientific definition and other names for this drug. Cladribine intravenous route description and brand names. One report indicates that concentrations are approximately 25% of those in plasma. Merck serono has applied for marketing approval of cladribine tablets in the european union, the united states and other locations. Cladribine injection is supplied as a sterile, preservativefree, isotonic solution containing 10 mg 1 mgml of cladribine as 10 ml filled into a singleuse clear flint glass vial, individually boxed.
Prospective observational longterm safety registry of multiple sclerosis participants who have participated in cladribine clinical trials premiere the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Highlights of prescribing information these highlights. Nov 16, 2016 cladribine plasma concentration after intravenous administration declines multiexponentially with an average halflife of 6. Aug 25, 2017 cladribine is a chemotherapeutic agent that targets white blood cells and is used to treat certain blood cancers.
Cladribine is a selective immune reconstitution therapy sirt which simplifies treatment administration, by giving patients just two short annual courses of tablets in four years. Cladribine fda prescribing information, side effects and uses. Pdf cladribine treatment in twohour intravenous infusion. For iv administration, reconstitute elspar by adding 5 ml sterile water for injection or sodium chloride injection to the 10,000 unit vial. Merck kgaa developed a pill formula for treating ms. Oral cladribine is contraindicated in breastfeeding women intending to breastfeed on a cladribine treatment day and for 10 days after the last dose. Leustatin injection is available in singleuse vials containing 10 mg 1 mgml of cladribine, a chlorinated purine nucleoside analog. Eight patients 57% responded to cladribine, including 2 14% complete response cr and 6 43% partial response pr. Optical character recognition converts nonselectable text from scanned documents into editable office files. Occasionally other additional software may be required such as powerpoint or adobe acrobat reader. The doctor had checked my lymphocyte count which was in the required range. If you want to display the pdf in your powerpoint presentation directly, you can insert it as an object.
Alternatively, you can rightclick a page and select insert pages to get the insert options. Apr 01, 2020 cladribine plasma concentration after intravenous administration declines multiexponentially with an average halflife of 6. Before using cladribine, tell your doctor or pharmacist if you are allergic to it. Nov 09, 2018 cladribine is a cancer medication that interferes with the growth and spread of cancer cells in the body. This medication is given by injection into a vein by a health care professional. Make sure everything that you want to capture as a picture. In the oraclems study, cladribine reduced conversion to ms compared with placebo 38% versus 14% for 3. In general, the apparent volume of distribution of cladribine is approximately 9 lkg, indicating an extensive distribution in body tissues. Cladribine is prescribed to help slow down the progression of hairy cell leukemia. Nov 16, 2016 what other drugs will affect cladribine leustatin. It is very slightly soluble in water and propan2ol and is soluble in 0.
Cladribine belongs to the group of medicines called antimetabolites. The primary apoptosisinducing mechanism of action of cdatp has direct and indirect actions on dna synthesis and mitochondrial function. The file is compressed and therefore the quality of the file itself is reduced but will now open for anyone who selects the link. Open powerpoint and display the slide where you want to insert the pdf graphic. It is an antineoplastic agent anticancer drug that is formulated for oral administration. Select create from file and navigate to the pdf file. My cladribine experience so far has been very straightforward and easy to deal with.